Manifold effects of Probiotics on Inflammation, Cognition, Dementia , Depression and Anxiety : A Traditional/Narrative Review - Possible choice of Non-pharmacological therapy at the level of primary care


  • Pranuthi Ratna
  • Aditi Sarker
  • Adarsh Srinivas Ramesh
  • Carlos Munoz
  • Dawood Jamil
  • Hadrian Hoang-Vu Tran``
  • Mafaz Mansoor
  • Samia Rauf R. Butt
  • Travis Satnarine
  • Lubna Mohammed



Probiotics, Inflammatory markers, OXIDATIVE STRESS, HUMAN MICROBIOME, Nervous System Diseases/diet therapy,Probiotics/therapeutic use, Microbiota/immunology, Alzheimer’s disease, Anxiety


Probiotics are microorganisms that can be included in
the diet or taken as supplements. They are widely
accessible and available at low cost to various
populations all over the world. This study aims to
gather both supporting and contradicting information
from previous studies and additionally discuss the
harmful effects of probiotics. Probiotics may offer
essential early intervention to lessen the severity of
inflammation, cognitive decline, and mood problems by
modifying the gut-brain axis in the body. They work on
multiple systems, so it is necessary to thoroughly
investigate their effects and efficacy through
randomized control trials in order to develop
therapeutic, affordable, and widely accessible
alternative treatment options from them for some of
the most prevalent health problems. A thorough search
was performed on various databases (PubMed,
ScienceDirect, and Google Scholar) using keywords and
nineteen studies that fit the inclusion/exclusion criteria
were deemed relevant.