The Inextricable Silent Connection: Unraveling the Link Between Atherosclerosis and Asthma
DOI:
https://doi.org/10.56570/jimgs.v2i1.88Keywords:
Asthma, atherosclerosis, arterial plaque, cardiovascular disease, inflammation, inflammatory cellsAbstract
Despite previous studies suggesting a possible association between atherosclerosis and asthma, the available data remains confined and isolated. This article delves into the correlation between these two diseases. By scrutinizing the existing literature highlighting shared risk factors and biomarkers between atherosclerosis and asthma, it becomes evident that the inflammatory cells common to both ailments may play a role in the pathogenesis of both disease processes. Some research sheds light on the protective effect of some asthma medications and the harmful aspect of others. An increasing body of evidence looks at the age of asthma onset and its association with atherosclerosis. Future research should focus on the early detection of atherosclerosis and addressing the tacit connection between atherosclerosis and asthma to improve the morbidity and mortality of those with asthma.References
Kumar V, Abbas AK, Aster JC. Blood Vessels. In: Robbins Basic Pathology. Elsevier Saunders; 2012:335-342.
Kumar V, Abbas AK, Aster JC. Lung. In: Robbins Basic Pathology. Elsevier Saunders; 2012:468-470.
Tuleta, I. et al. (2017) ‘Asthma is associated with atherosclerotic artery changes’, PLOS ONE, 12(10). doi:10.1371/journal.pone.0186820.
Yılmaz, M., Bozkurt Yılmaz, H. E., Şen, N., Altın, C., Tekin, A., & Müderrisoğlu, H. (2018). Investigation of the relationship between asthma and subclinical atherosclerosis by carotid/femoral intima media and epicardial fat thickness measurement. Journal of Asthma, 55(1), pp 50-56. doi: https://doi.org/10.1080/02770903.2017.1313272
Tattersall, M.C. et al. (2015) ‘Asthma predicts cardiovascular disease events’, Arteriosclerosis, Thrombosis, and Vascular Biology, 35(6), pp. 1520–1525. doi:10.1161/atvbaha.115.305452.
Schanen, J.G. (2005) ‘Asthma and incident cardiovascular disease: The atherosclerosis risk in communities study’, Thorax, 60(8), pp. 633–638. doi:10.1136/thx.2004.026484.
Liu, C.-L., Zhang, J.-Y. and Shi, G.-P. (2016) ‘Interaction between allergic asthma and atherosclerosis’, Translational Research, 174, pp. 5–22. doi:10.1016/j.trsl.2015.09.009.
Podgórski, M. et al. (2017) ‘Inhaled corticosteroids in asthma: Promoting or protecting against atherosclerosis?’, Medical Science Monitor, 23, pp. 5337–5344. doi:10.12659/msm.904469.
Otsuki, M. et al. (2010) ‘Reduced carotid atherosclerosis in asthmatic patients treated with inhaled corticosteroids’, European Respiratory Journal, 36(3), pp. 503–508. doi:10.1183/09031936.00090009.
Yao, C.-W. et al. (2016) ‘Asthma is associated with a subsequent risk of peripheral artery disease’, Medicine, 95(3). doi:10.1097/md.0000000000002546.
Onufrak, S., Abramson, J. and Vaccarino, V. (2007) ‘Adult-onset asthma is associated with increased carotid atherosclerosis among women in The atherosclerosis risk in communities (ARIC) study’, Atherosclerosis. doi:10.1016/j.atherosclerosis.2006.09.004.
Ulger, Z., Gulen, F., & Ozyurek, A. R. (2015). Abdominal aortic stiffness as a marker of atherosclerosis in childhood-onset asthma: a case-control study: cardiovascular topics. Cardiovascular Journal Of Africa, 26(1), pp. 8-12. doi: https://journals.co.za/doi/abs/10.5830/CVJA-2014-046
Iribarren, C. et al. (2012) ‘Adult asthma and risk of coronary heart disease, cerebrovascular disease, and heart failure: A prospective study of 2 matched cohorts’, American Journal of Epidemiology, 176(11), pp. 1014–1024. doi:10.1093/aje/kws181.
