Role of Gray Matter in Depression and Ways to Overcome Depression Using Appropriate Medications and Psychological Therapy
DOI:
https://doi.org/10.56570/jimgs.v1i2.39Keywords:
Depression, Gray matter, cognitive Therapy, MRIAbstract
Depression is a mental state when one feels helpless
and unable to control different thoughts and has
difficulty accomplishing daily tasks. The reduction of
gray matter is noticeable in depression, especially in
major depression disorder. There are various
Psychological and medical treatments available for
depression disorder, such as cognitive therapy and
drugs like Ginkgo Biloba and Glutathione. Gingko Biloba
plays a role in dementia and cerebral deficiencies. At
the same time, glutathione is an antioxidant that
prevents the brain from reacting with oxygen species
and is good at maintaining cellular thiol status.
Glutathione also removed depressive-like behavior in
mice through its oral administration. The time taken by
each therapy is approximately 3-6 months. Cognitive
therapy works by altering thinking patterns, and if it is
combined with medication therapy of GSH and Gingko
Biloba, calculating the appropriate dose early and longlasting results can appear. Where drugs will help in
replenishing the gray matter and fluids that our brain
requires for proper working.
References
Bibring E. The mechanism of depression. 1953.
Wise T, Radua J, Via E, Cardoner N, Abe O, Adams TM, et al. Common and distinct patterns of grey-matter volume alteration in major depression and bipolar disorder: evidence from a voxel-based meta-analysis. Molecular psychiatry. 2017;22(10):1455-63.
Mahmud S, Hossain S, Muyeed A, Islam MM, Mohsin M. The global prevalence of depression, anxiety, stress, and insomnia and its changes among health professionals during COVID-19 pandemic: A rapid systematic review and meta-analysis. Heliyon. 2021;7(7):e07393.
Fitzpatrick OM, Whelen ML, Falkenström F, Strunk DR. Who benefits the most from the cognitive change in cognitive therapy of depression? A study of interpersonal factors. Journal of consulting and clinical psychology. 2020;88(2):128.
Young JE, Rygh JL, Weinberger AD, Beck AT. Cognitive therapy for depression. 2014.
Bruno G. Brain Nutrients.
Dwivedi D, Megha K, Mishra R, Mandal PK. Glutathione in the brain: an overview of its conformations, functions, biochemical characteristics, quantitation and potential therapeutic role in brain disorders. Neurochemical Research. 2020;45(7):1461-80.
