Effectiveness of a Ketogenic Diet in Children With Refractory Epilepsy: A Systemic Review
DOI:
https://doi.org/10.56570/jimgs.v3i2.169Keywords:
Refractory epilepsy, Ketogenic diet, Children (pediatrics), Seizure reduction, Systematic review (PRISMA)Abstract
A notable proportion (10%-20%) of children with epilepsy remain unresponsive to pharmacological treatment. Current strategies for the management of refractory epilepsy encompass surgical treatments (vagus nerve stimulation) as well as the adoption of a Ketogenic Diet. By adhering to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, we conducted a systematic review to identify all relevant studies in English language that investigated the effectiveness of a Ketogenic diet in children with refractory epilepsy. A total of 125 studies were identified and eight, involving a total of 1330 patients, met the criteria. Of the identified eight studies, one was randomized controlled trial, one was systematic review/meta-analysis, and the rest were observational studies. More than half (54%) of the participants reported seizure resolution, while 17% became seizure-free after one month of initiating the ketogenic diet. Ketogenic diet have been shown to be efficacious for the treatment of epilepsy in infants.References
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