Unlocking the Power of Probiotics: A Comprehensive Review on Safeguarding Hospitalised Patients From Clostridium Difficle Infection
DOI:
https://doi.org/10.56570/jimgs.v2i2.107Keywords:
probiotics, clostridium difficile, lactobacillus, pseudomembranous colitis, microbiota, prebiotics and antibiotic associated diarrhoeaAbstract
Antibiotic-associated diarrhea (AAD) is a common complication of antibiotic therapy, with Clostridium difficile infection (CDI) being a major cause of severe AAD. CDI is associated with high morbidity, mortality, and healthcare costs. The administration of probiotics is a promising strategy for the prevention of AAD and CDI, as they can create a favorable gut environment and alter the composition of the intestinal flora. This systematic review evaluated the use of probiotics in preventing CDI in hospitalized adult patients. The review of 12 randomized controlled trials involving 3,586 patients found that probiotics reduced the incidence of CDI in hospitalized adult patients by up to 70%. Specifically, the probiotic strains Lactobacillus rhamnosus GG and Saccharomyces boulardii were found to be effective in preventing CDI. However, further research is needed to establish optimal dosing regimens and to identify the most effective probiotic strains for CDI prevention. Nonetheless, the use of probiotics appears to be a promising strategy for reducing the incidence of CDI in hospitalized adult patients receiving antibiotics.References
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