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  <front>
    <journal-meta>
      <journal-id journal-id-type="ojs">journal</journal-id>
      <journal-title-group>
        <journal-title xml:lang="en">Journal For International Medical Graduates</journal-title>
        <abbrev-journal-title xml:lang="en">Journal For International Medical Graduates</abbrev-journal-title>
      </journal-title-group>
      <publisher>
        <publisher-name>California Institute of Behavioral Neurosciences and Psychology</publisher-name>
        <publisher-loc>
          <country>US</country>
          <uri>https://www.cibnp.com</uri>
        </publisher-loc>
      </publisher>
      <issn pub-type="epub">2832-9864</issn>
      <self-uri xlink:href="https://www.jimgs.com/ojs/index.php/journal"/>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id">99</article-id>
      <article-categories>
        <subj-group xml:lang="en" subj-group-type="heading">
          <subject>Articles</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title xml:lang="en">Manifold Effects of Probiotics on Inflammation, Cognition, Dementia, Depression and Anxiety: A Traditional/Narrative Review – Possible Choice of Non-pharmacological Therapy at the Level of Primary Care</article-title>
      </title-group>
      <contrib-group content-type="author">
        <contrib corresp="yes">
          <name-alternatives>
            <string-name specific-use="display">Pranuthi Ratna</string-name>
            <name name-style="western" specific-use="primary">
              <surname>Ratna</surname>
              <given-names>Pranuthi</given-names>
            </name>
          </name-alternatives>
          <email>pranuthi.ratna@jimgs.com</email>
        </contrib>
        <contrib>
          <name-alternatives>
            <string-name specific-use="display">Aditi Sarker</string-name>
            <name name-style="western" specific-use="primary">
              <surname>Sarker</surname>
              <given-names>Aditi</given-names>
            </name>
          </name-alternatives>
          <email>aditixavier14@gmail.com</email>
        </contrib>
        <contrib>
          <name-alternatives>
            <string-name specific-use="display">Adarsh Srinivas Ramesh</string-name>
            <name name-style="western" specific-use="primary">
              <surname>Ramesh</surname>
              <given-names>Adarsh Srinivas</given-names>
            </name>
          </name-alternatives>
          <email>adarsh.srinivas.ramesh@jimgs.com</email>
        </contrib>
        <contrib>
          <name-alternatives>
            <string-name specific-use="display">Carlos Munoz</string-name>
            <name name-style="western" specific-use="primary">
              <surname>Munoz</surname>
              <given-names>Carlos</given-names>
            </name>
          </name-alternatives>
          <email>carlos.munoz@jimgs.com</email>
        </contrib>
        <contrib>
          <name-alternatives>
            <string-name specific-use="display">Dawood Jamil</string-name>
            <name name-style="western" specific-use="primary">
              <surname>Jamil</surname>
              <given-names>Dawood</given-names>
            </name>
          </name-alternatives>
          <email>dawood.jamil@jimgs.com</email>
        </contrib>
        <contrib>
          <name-alternatives>
            <string-name specific-use="display">Hadrian Hoang-Vu Tran</string-name>
            <name name-style="western" specific-use="primary">
              <surname>Tran</surname>
              <given-names>Hadrian Hoang-Vu</given-names>
            </name>
          </name-alternatives>
          <email>hadrian.hoang-vu.tran@jimgs.com</email>
        </contrib>
        <contrib>
          <name-alternatives>
            <string-name specific-use="display">Mafaz Mansoor</string-name>
            <name name-style="western" specific-use="primary">
              <surname>Mansoor</surname>
              <given-names>Mafaz</given-names>
            </name>
          </name-alternatives>
          <email>mafaz.mansoor@jimgs.com</email>
        </contrib>
        <contrib>
          <name-alternatives>
            <string-name specific-use="display">Samia Rauf R. Butt</string-name>
            <name name-style="western" specific-use="primary">
              <surname>Butt</surname>
              <given-names>Samia Rauf R.</given-names>
            </name>
          </name-alternatives>
          <email>samia.rauf.r.butt@jimgs.com</email>
        </contrib>
        <contrib>
          <name-alternatives>
            <string-name specific-use="display">Travis Satnarine</string-name>
            <name name-style="western" specific-use="primary">
              <surname>Satnarine</surname>
              <given-names>Travis</given-names>
            </name>
          </name-alternatives>
          <email>travis.satnarine@jimgs.com</email>
        </contrib>
        <contrib>
          <name-alternatives>
            <string-name specific-use="display">Lubna Mohammed</string-name>
            <name name-style="western" specific-use="primary">
              <surname>Mohammed</surname>
              <given-names>Lubna</given-names>
            </name>
          </name-alternatives>
          <email>doclubna23@gmail.com</email>
        </contrib>
      </contrib-group>
      <pub-date date-type="pub" publication-format="epub">
        <day>09</day>
        <month>06</month>
        <year>2023</year>
      </pub-date>
      <pub-history>
        <event event-type="received">
          <event-desc>Received: <date date-type="received" iso-8601-date="2023-06-09T09:23:31+00:00"><day>9</day><month>6</month><year>2023</year></date></event-desc>
        </event>
      </pub-history>
      <permissions>
        <copyright-statement>Copyright (c) 2023 Journal For International Medical Graduates</copyright-statement>
        <copyright-year>2023</copyright-year>
        <copyright-holder>Journal For International Medical Graduates</copyright-holder>
      </permissions>
      <self-uri xlink:href="https://www.jimgs.com/ojs/index.php/journal/article/view/99"/>
      <kwd-group xml:lang="en">
        <kwd>Probiotics</kwd>
        <kwd>Inflammatory markers</kwd>
        <kwd>Oxidative Stress</kwd>
        <kwd>Human Microbiome</kwd>
        <kwd>Nervous System Diseases/diet therapy</kwd>
        <kwd>Probiotics/therapeutic use</kwd>
        <kwd>Microbiota/immunology</kwd>
        <kwd>Alzheimer’s disease</kwd>
        <kwd>Anxiety</kwd>
      </kwd-group>
      <custom-meta-group/>
    </article-meta>
  </front>
  <body/>
  <back>
    <ref-list>
      <ref id="R1">
        <mixed-citation>Tsiompanou E &amp; Marketos SG : Hippocrates: timeless still. Journal of the Royal Society of Medicine. 2013, 106:288-292. 10.1177/0141076813492945</mixed-citation>
      </ref>
      <ref id="R2">
        <mixed-citation>Huang R, Wang K, &amp; Hu J. : Effect of probiotics on depression: a systematic review and meta-analysis of randomized controlled trials. Nutrients. 2016, 8:483. 10.3390/nu8080483</mixed-citation>
      </ref>
      <ref id="R3">
        <mixed-citation>Pourrajab B, Fatahi S, Sohouli MH, et al.: The effects of probiotic/synbiotic supplementation compared to placebo on biomarkers of oxidative stress in adults: a systematic review and meta-analysis of randomized controlled trials. Critical reviews in food science and nutrition. 2022, 62:490-507. 10.1080/10408398.2020.1821166</mixed-citation>
      </ref>
      <ref id="R4">
        <mixed-citation>Zamani B, Sheikhi A, Namazi N, et al..: The effects of supplementation with probiotic on biomarkers of oxidative stress in adult subjects: a systematic review and meta-analysis of randomized trials. . 2020. 10.1007/s12602-018-9500-1</mixed-citation>
      </ref>
      <ref id="R5">
        <mixed-citation>Qu H, Zhang Y, Chai H, et al.: Effects of microbiota-driven therapy on inflammatory responses in elderly individuals: a systematic review and meta-analysis. . 2019. 10.1371/journal.pone.0211233</mixed-citation>
      </ref>
      <ref id="R6">
        <mixed-citation>Park MR, Shin M, Mun D, et al.: Probiotic lactobacillus fermentum strain JDFM216 improves cognitive behavior and modulates immune response with gut microbiota.. Scientific reports, 10. 2020, 21701:10.1038/s41598-020-77587-w</mixed-citation>
      </ref>
      <ref id="R7">
        <mixed-citation>Anastasiya S, Andre CF, Danielle CS, et al.: Gut emotions - mechanisms of action of probiotics as novel therapeutic targets for depression and anxiety disorders. CNS &amp; neurological disorders drug targets. 2014, 13:1770-1786. 10.2174/1871527313666141130205242</mixed-citation>
      </ref>
      <ref id="R8">
        <mixed-citation>Milajerdi A, Mousavi SM, Sadeghi A, et al.: The effect of probiotics on inflammatory biomarkers: a meta-analysis of randomized clinical trials. European journal of nutrition. 2020, 59:633-649. 10.1007/s00394-019-01931-8</mixed-citation>
      </ref>
      <ref id="R9">
        <mixed-citation>Heshmati J, Farsi F, Shokri F, et al.: A systematic review and meta-analysis of the probiotics and synbiotics effects on oxidative stress.. Journal of Functional Foods.. 2018, 46:66-84. 10.1016/j.jff.2018.04.049</mixed-citation>
      </ref>
      <ref id="R10">
        <mixed-citation>Li X, Lv C, Song J et al.: Effect of probiotic supplementation on cognitive function and metabolic status in mild cognitive impairment and alzheimer's disease: a meta-analysis. Frontiers. 2021, 8:757673. 10.3389/fnut.2021.757673</mixed-citation>
      </ref>
      <ref id="R11">
        <mixed-citation>Mazidi M, Rezaie P, Ferns GA, et al.: Impact of probiotic administration on serum c-reactive protein concentrations: systematic review and meta-analysis of randomized control trials. Nutrients. 2017, 9:20. 10.3390/nu9010020</mixed-citation>
      </ref>
      <ref id="R12">
        <mixed-citation>Xiang S, Ji JL, Li S, et al.: Efficacy and safety of probiotics for the treatment of alzheimer's disease, mild cognitive impairment, and parkinson's disease: a systematic review and meta-analysis. Frontiers in aging neuroscience. 2022, 14:730036. 10.3389/fnagi.2022.730036</mixed-citation>
      </ref>
      <ref id="R13">
        <mixed-citation>Mental disorders - WHO. (2022). https://www.who.int/news-room/fact-sheets/detail/mental-disorders.</mixed-citation>
      </ref>
      <ref id="R14">
        <mixed-citation>Baxter AJ, Scott KM, Vos T, et al.: Global prevalence of anxiety disorders: a systematic review and meta-regression. Psychological Medicine. 2013, 43:897-910. 10.1017/S003329171200147X</mixed-citation>
      </ref>
      <ref id="R15">
        <mixed-citation>Chao L, Liu C, Sutthawongwadee S, et al.: Effects of probiotics on depressive or anxiety variables in healthy participants under stress conditions or with a depressive or anxiety diagnosis: a meta-analysis of randomized controlled trials. Frontiers in neurology. 2020, 11:421. 10.3389/fneur.2020.00421</mixed-citation>
      </ref>
      <ref id="R16">
        <mixed-citation>Foster JA &amp; Neufeld KAM: Gut-brain axis: how the microbiome influences anxiety and depression, trends in neurosciences. Trends in neurosciences.. 2013. 36:305 - 312. 10.1016/j.tins.2013.01.005</mixed-citation>
      </ref>
      <ref id="R17">
        <mixed-citation>Agahi A, Hamidi GA, Daneshvar R, et al.: Does severity of alzheimer's disease contribute to its responsiveness to modifying gut microbiota? A double blind clinical trial. Frontiers in neurology. 2018, 9:10.3389/fneur.2018.00662</mixed-citation>
      </ref>
      <ref id="R18">
        <mixed-citation>Rojek AZ, Tyski S: Are probiotic really safe for humans?. Polish journal of microbiology. 2018, 67:251-258. 10.21307/pjm-2018-044</mixed-citation>
      </ref>
      <ref id="R19">
        <mixed-citation>Sniffen JC, McFarland LV, Evans CT, et al.: Choosing an appropriate probiotic product for your patient: an evidence-based practical guide. . 2018. 10.1371/journal.pone.0209205</mixed-citation>
      </ref>
      <ref id="R20">
        <mixed-citation>Jenks K, Stebbings S, Burton J, et al.: Probiotic therapy for the treatment of spondyloarthritis: a randomized controlled trial.. Journal of rheumatology. 2010, 37:2118-2125. 10.3899/jrheum.100193</mixed-citation>
      </ref>
      <ref id="R21">
        <mixed-citation>Custodero C, Mankowski RT, Lee SA, et al.: Evidence-based nutritional and pharmacological interventions targeting chronic low-grade inflammation in middle-age and older adults: A systematic review and meta-analysis. Ageing research reviews. 2018, 46:42-59. 10.1016/j.arr.2018.05.004</mixed-citation>
      </ref>
      <ref id="R22">
        <mixed-citation>Marco SD, Sichetti M, Muradyan D, et al.: Probiotic cell-free supernatants exhibited anti-inflammatory and antioxidant activity on human gut epithelial cells and macrophages stimulated with LPS. Evidence-based complementary and alternative medicine : eCAM. 2018, 1756308:10.1155/2018/1756308</mixed-citation>
      </ref>
      <ref id="R23">
        <mixed-citation>Jiménez CT, Ramírez MJM, Gil A, et al.: Effects of probiotics on metabolic syndrome: a systematic review of randomized clinical trials. . 2020, 10.3390/nu12010124</mixed-citation>
      </ref>
      <ref id="R24">
        <mixed-citation>Zhu G, Zhao J, Zhang H, et al.: Probiotics for mild cognitive impairment and alzheimer's disease: a systematic review and meta-analysis.. 2021 (ed): 10.3390/foods10071672</mixed-citation>
      </ref>
      <ref id="R25">
        <mixed-citation>Alkasir R, Li J, Li X, et al.: Human gut microbiota: the links with dementia development. 2017, 8:90-102. 10.1007/s13238-016-0338-6</mixed-citation>
      </ref>
      <ref id="R26">
        <mixed-citation>Tamtaji OR, Milajerdi A, Reiner Z, et al.: A systematic review and meta-analysis: the effects of probiotic supplementation on metabolic profile in patients with neurological disorders.. 2020, 10.1016/j.ctim.2020.102507</mixed-citation>
      </ref>
      <ref id="R27">
        <mixed-citation>Krüger JF, Hillesheim E, Pereira ACSN, et al.: Probiotics for dementia: a systematic review and meta-analysis of randomized controlled trials. Nutrition reviews. 2021, 79:160-170. 10.1093/nutrit/nuaa037</mixed-citation>
      </ref>
      <ref id="R28">
        <mixed-citation>Qiu X, Wu G, Wang L, et al.: Lactobacillus delbrueckii alleviates depression-like behavior through inhibiting toll-like receptor 4 signaling in mice. Annals of translational medicine. 2021, 9:366-10. 10.21037/atm-20-4411</mixed-citation>
      </ref>
      <ref id="R29">
        <mixed-citation>Amirani E, Milajerdi A, Mirzaei H, et al.: The effects of probiotic supplementation on mental health, biomarkers of inflammation and oxidative stress in patients with psychiatric disorders: a systematic review and meta-analysis of randomized controlled trials. . 2020. 10.1016/j.ctim.2020.102361</mixed-citation>
      </ref>
      <ref id="R30">
        <mixed-citation>Minayo MS, Miranda I and Telhado RS: A systematic review of the effects of probiotics on depression and anxiety: an alternative therapy?. 2020, 26:4087-4099. 10.1590/1413-81232021269.21342020</mixed-citation>
      </ref>
      <ref id="R31">
        <mixed-citation>Borriello S, Hammes WP, Holzapfel W, et al.: Safety of probiotics that contain lactobacilli or bifidobacteria. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2003, 36:775-780. 10.1086/368080</mixed-citation>
      </ref>
      <ref id="R32">
        <mixed-citation>Ishibashi N, Yamazaki S: Probiotics and safety. American journal of clinical nutrition. 2001, 73:2. 10.1093/ajcn/73.2.465s</mixed-citation>
      </ref>
      <ref id="R33">
        <mixed-citation>Doron S &amp; Snydman DR : Risk and safety of probiotics. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2015, 60:2. 10.1093/cid/civ085</mixed-citation>
      </ref>
      <ref id="R34">
        <mixed-citation>Boyle RJ, Browne RMR, Tang MLK: Probiotic use in clinical practice: what are the risks?. American journal of clinical nutrition. 2006, 83:1256-1447. 10.1093/ajcn/83.6.1256</mixed-citation>
      </ref>
      <ref id="R35">
        <mixed-citation>Katkowska M, Garbacz K, &amp; Kusiak A: Probiotics: should all patients take them?. 2021, 9:2620. 10.3390/microorganisms9122620</mixed-citation>
      </ref>
      <ref id="R36">
        <mixed-citation>Stanton C, Gardiner G, Meehan H, et al.: Market potential for probiotics. . American journal of clinical nutrition. 2001, 73:2. 10.1093/ajcn/73.2.476s</mixed-citation>
      </ref>
      <ref id="R37">
        <mixed-citation>Young SL, Simon MA, Baird MA, et al.: Bifidobacterial species differentially affect expression of cell surface markers and cytokines of dendritic cells harvested from cord blood. . Clinical and diagnostic laboratory immunology. 2004. 11:686-690. 10.1128/CDLI.11.4.686-690.2004</mixed-citation>
      </ref>
      <ref id="R38">
        <mixed-citation>Nahoum SR, Paglino J, Varzaneh FE, et al.: Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis. Cell. 2004, 118:229-241. 10.1016/j.cell.2004.07.002</mixed-citation>
      </ref>
      <ref id="R39">
        <mixed-citation>Christensen HR, Frøkiaer H, Pestka JJ: Lactobacilli differentially modulate expression of cytokines and maturation surface markers in murine dendritic cells.. Journal of immunology (Baltimore, Md). 2002, 168:171-178. 10.4049/jimmunol.168.1.171</mixed-citation>
      </ref>
    </ref-list>
  </back>
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