journal Journal For International Medical Graduates Journal For International Medical Graduates California Institute of Behavioral Neurosciences and Psychology US https://www.cibnp.com 2832-9864 39 Articles Role of Gray Matter in Depression and Ways to Overcome Depression Using Appropriate Medications and Psychological Therapy Abdul Manan Manan Abdul abdul.manan@jimgs.com Sadi-UL-Haq UL-Haq Sadi sadi.ul-haq@jimgs.com Mudassir Shahbaz Shahbaz Mudassir mudassir.shahbaz@jimgs.com Seemab Sunam Sunam Seemab seemab.sunam@jimgs.com California Institute of Behavioral Neurosciences and Psychology (United States) https://ror.org/01ytd2n62 11 10 2022 Received: 11102022 Copyright (c) 2022 Journal For International Medical Graduates 2022 Journal For International Medical Graduates Depression Gray matter cognitive Therapy MRI production-ready-file-url Bibring E. The mechanism of depression. 1953. Wise T, Radua J, Via E, Cardoner N, Abe O, Adams TM, et al. Common and distinct patterns of grey-matter volume alteration in major depression and bipolar disorder: evidence from a voxel-based meta-analysis. Molecular psychiatry. 2017;22(10):1455-63. Mahmud S, Hossain S, Muyeed A, Islam MM, Mohsin M. The global prevalence of depression, anxiety, stress, and insomnia and its changes among health professionals during COVID-19 pandemic: A rapid systematic review and meta-analysis. Heliyon. 2021;7(7):e07393. Fitzpatrick OM, Whelen ML, Falkenström F, Strunk DR. Who benefits the most from the cognitive change in cognitive therapy of depression? A study of interpersonal factors. Journal of consulting and clinical psychology. 2020;88(2):128. Young JE, Rygh JL, Weinberger AD, Beck AT. Cognitive therapy for depression. 2014. Bruno G. Brain Nutrients. Dwivedi D, Megha K, Mishra R, Mandal PK. Glutathione in the brain: an overview of its conformations, functions, biochemical characteristics, quantitation and potential therapeutic role in brain disorders. Neurochemical Research. 2020;45(7):1461-80.