journal Journal For International Medical Graduates Journal For International Medical Graduates California Institute of Behavioral Neurosciences and Psychology US https://www.cibnp.com 2832-9864 179 Articles Efficacy of Negative Pressure Wound Therapy on Management of Surgical Site Infections: A Systematic Review of Randomized Clinical Trials Reshmitha Kantamnen Kantamnen Reshmitha kantamnenireshmitha@gmail.com Tirath Patel Patel Tirath tirathp611@gmail.com Arnesh Shukla Shukla Arnesh arneshshukla@gmail.com Ayesha Salma Salma Ayesha salmaayesha720@gmail.com Dev Patel Patel Dev devpatel1618@gmail.com Jabez David John John Jabez David dr.jsbezdavid@gmail.com Sarath Chandra Ponnada Ponnada Sarath Chandra sarathponnada558@gmail.com Ketan Kantamneni Kantamneni Ketan kantamnenikethan@gmail.com Tuheen Sankar Nath Nath Tuheen Sankar tuheen1996@gmail.com Rangaraya Medical College, Dr YSR University of Health Sciences Trinity Medical Sciences University School of Medicine St Martinus University Shadan Institute of Medical Sciences Lokmanya Tilak Municipal Medical College Malla Reddy Institute of Medical Science Great Eastern Medical School and Hospital, Srikakulam Trauma and Orthopaedics, East Kent University Hospitals NHS Foundation Trust, Ashford, GBR California Institute of Behavioral Neurosciences & Psychology Fairfield, USA 22 02 2025 Received: 2222025 Copyright (c) 2024 Journal For International Medical Graduates 2024 Journal For International Medical Graduates Negative pressure wound therapy Vacuum-assisted wound therapy Vacuum-Assisted Closure (VAC) Wound care techniques Advanced wound care Postoperative Care Arad M, Goli R, Ebrahimzade M, Lorzini M, Abdali M, Sepehrnia N. Ending surgical site infection by negative pressure wound therapy (NPWT): A case report. Int J Surg Case Rep. 2022;94:107080. Doi:10.1016/j.ijscr.2022.107080 Lenet T, Gilbert RWD, Abou-Khalil J, Balaa FK, Martel G, Brind'Amour A, et al. The impact of prophylactic negative pressure wound therapy on surgical site infections in pancreatic resection: A systematic review and meta-analysis. HPB (Oxf). 2022;24(12):2035-44. Doi:10.1016/j.hpb.2022.08.010 Scalise A, Calamita R, Tartaglione C, et al. Improving wound healing and preventing surgical site complications of closed surgical incisions: a possible role of incisional negative pressure wound therapy. A systematic review of the literature. Int Wound J. 2016;13(6):1260-81. Doi:10.1111/iwj.12492 Sinha S. Management of post-surgical wounds in general practice. Aust J Gen Pract. 2019;48(8):596-9. doi:10.31128/AJGP-04-19-4921 Dumville JC, Owens GL, Crosbie EJ, Peinemann F, Liu Z. Negative pressure wound therapy for treating surgical wounds healing by secondary intention. Cochrane Database Syst Rev. 2015;4:CD011278. doi:10.1002/14651858.CD011278.pub2 Robert N. Negative pressure wound therapy in orthopaedic surgery. Orthop Traumatol Surg Res. 2017;103(1S):S99-103. doi:10.1016/j.otsr.2016.04.018 Svensson-Björk R, Hasselmann J, Asciutto G, et al. Negative pressure wound therapy for the prevention of surgical site infections using fascia closure after EVAR: A randomized trial. World J Surg. 2022;46(11):3111-20. doi:10.1007/s00268-022-06740-5 Lee K, Murphy PB, Ingves MV, et al. Randomized clinical trial of negative pressure wound therapy for high-risk groin wounds in lower extremity revascularization. J Vasc Surg. 2017;66(6):1814-9. Doi:10.1016/j.jvs.2017.06.084 Monsen C, Acosta S, Mani K, Wann-Hansson C. A randomized study of NPWT closure versus alginate dressings in peri-vascular groin infections: quality of life, pain, and cost. J Wound Care. 2015;24(6):254-6. Doi:10.12968/jowc.2015.24.6.252 Pachowsky M, Gusinde J, Klein A, et al. Negative pressure wound therapy to prevent seromas and treat surgical incisions after total hip arthroplasty. Int Orthop. 2012;36(4):719-22. doi:10.1007/s00264-011-1321-8 Mody GN, Nirmal IA, Duraisamy S, Perakath B. A blinded, prospective, randomized controlled trial of topical negative pressure wound closure in India. Ostomy Wound Manage. 2008;54(6):36-46. Chau WW, Lo KC, Lau LC, Ong MT, Ho KK. Single-use negative pressure wound therapy (NPWT) system in the management of knee arthroplasty. BMC Musculoskelet Disord. 2023;24:186. doi:10.1186/s12891-023-06470-2 Karlakki SL, Hamad AK, Whittall C, Graham NM, Banerjee RD, Kuiper JH. Incisional negative pressure wound therapy dressings (iNPWTd) in routine primary hip and knee arthroplasties: A randomised controlled trial. Bone Joint Res. 2016;5(8):328-37. doi:10.1302/2046-3758.58.BJR-2016-0022.R1 Blume PA, Walters J, Payne W, Ayala J, Lantis J. Comparison of negative pressure wound therapy using vacuum-assisted closure with advanced moist wound therapy in the treatment of diabetic foot ulcers: A multicenter randomized controlled trial. Diabetes Care. 2008;31(4):631-6. doi:10.2337/dc07-2196 Benrashid E, Youngwirth LM, Guest K, Cox MW, Shortell CK, Dillavou ED. Negative pressure wound therapy reduces surgical site infections. J Vasc Surg. 2020;71(3):896-904. doi:10.1016/j.jvs.2019.05.066