<?xml version="1.0" encoding="UTF-8"?>
<article xmlns:xlink="http://www.w3.org/1999/xlink" xml:lang="en" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
  <front>
    <journal-meta>
      <journal-id journal-id-type="ojs">journal</journal-id>
      <journal-title-group>
        <journal-title xml:lang="en">Journal For International Medical Graduates</journal-title>
        <abbrev-journal-title xml:lang="en">Journal For International Medical Graduates</abbrev-journal-title>
      </journal-title-group>
      <publisher>
        <publisher-name>California Institute of Behavioral Neurosciences and Psychology</publisher-name>
        <publisher-loc>
          <country>US</country>
          <uri>https://www.cibnp.com</uri>
        </publisher-loc>
      </publisher>
      <issn pub-type="epub">2832-9864</issn>
      <self-uri xlink:href="https://www.jimgs.com/ojs/index.php/journal"/>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id">149</article-id>
      <article-categories>
        <subj-group xml:lang="en" subj-group-type="heading">
          <subject>Articles</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title xml:lang="en">Role of Proprotein Convertase Subtilisin Kexin Type 9 Inhibitor Therapy in Treatment of Patients With Polycystic Ovary Syndrome: A Systemic Review of Metabolic and Cardiovascular Outcomes</article-title>
      </title-group>
      <contrib-group content-type="author">
        <contrib corresp="yes">
          <name-alternatives>
            <string-name specific-use="display">Dev Patel</string-name>
            <name name-style="western" specific-use="primary">
              <surname>Patel</surname>
              <given-names>Dev</given-names>
            </name>
          </name-alternatives>
          <email>devpatel1618@gmail.com</email>
          <xref ref-type="aff" rid="aff-1"/>
        </contrib>
        <contrib>
          <name-alternatives>
            <string-name specific-use="display">Jabez John</string-name>
            <name name-style="western" specific-use="primary">
              <surname>John</surname>
              <given-names>Jabez</given-names>
            </name>
          </name-alternatives>
          <email>jabez.john@jimgs.com</email>
        </contrib>
        <contrib>
          <name-alternatives>
            <string-name specific-use="display">Ranita Bodepudi</string-name>
            <name name-style="western" specific-use="primary">
              <surname>Bodepudi</surname>
              <given-names>Ranita</given-names>
            </name>
          </name-alternatives>
          <email>ranita.bodepudi@jimgs.com</email>
        </contrib>
        <contrib>
          <name-alternatives>
            <string-name specific-use="display">Saniya Seher</string-name>
            <name name-style="western" specific-use="primary">
              <surname>Seher</surname>
              <given-names>Saniya</given-names>
            </name>
          </name-alternatives>
          <email>saniya.seher@jimgs.com</email>
        </contrib>
        <contrib>
          <name-alternatives>
            <string-name specific-use="display">Shenel Khan</string-name>
            <name name-style="western" specific-use="primary">
              <surname>Khan</surname>
              <given-names>Shenel</given-names>
            </name>
          </name-alternatives>
          <email>shenel.khan@jimgs.com</email>
        </contrib>
        <contrib>
          <name-alternatives>
            <string-name specific-use="display">Soniya Emmanuel</string-name>
            <name name-style="western" specific-use="primary">
              <surname>Emmanuel</surname>
              <given-names>Soniya</given-names>
            </name>
          </name-alternatives>
          <email>soniya.emmanuel@jimgs.com</email>
        </contrib>
        <contrib>
          <name-alternatives>
            <string-name specific-use="display">Vivig Shantha</string-name>
            <name name-style="western" specific-use="primary">
              <surname>Shantha</surname>
              <given-names>Vivig</given-names>
            </name>
          </name-alternatives>
          <email>vivig.shantha@jimgs.com</email>
        </contrib>
        <contrib>
          <name-alternatives>
            <string-name specific-use="display">Resheek Nerella</string-name>
            <name name-style="western" specific-use="primary">
              <surname>Nerella</surname>
              <given-names>Resheek</given-names>
            </name>
          </name-alternatives>
          <email>resheek.nerella@jimgs.com</email>
        </contrib>
        <contrib>
          <name-alternatives>
            <string-name specific-use="display">Basim Shaman</string-name>
            <name name-style="western" specific-use="primary">
              <surname>Shaman</surname>
              <given-names>Basim</given-names>
            </name>
          </name-alternatives>
          <email>basim.shaman@jimgs.com</email>
        </contrib>
        <contrib>
          <name-alternatives>
            <string-name specific-use="display">Pousette Hamid</string-name>
            <name name-style="western" specific-use="primary">
              <surname>Hamid</surname>
              <given-names>Pousette</given-names>
            </name>
          </name-alternatives>
          <email>pousette.hamid@jimgs.com</email>
        </contrib>
      </contrib-group>
      <aff id="aff-1">
        <institution content-type="orgname">California Institute of Behavioural Neurosciences &amp; Psychology</institution>
      </aff>
      <pub-date date-type="pub" publication-format="epub">
        <day>19</day>
        <month>02</month>
        <year>2024</year>
      </pub-date>
      <pub-history>
        <event event-type="received">
          <event-desc>Received: <date date-type="received" iso-8601-date="2024-02-19T10:46:47+00:00"><day>19</day><month>2</month><year>2024</year></date></event-desc>
        </event>
      </pub-history>
      <permissions>
        <copyright-statement>Copyright (c) 2024 Journal For International Medical Graduates</copyright-statement>
        <copyright-year>2024</copyright-year>
        <copyright-holder>Journal For International Medical Graduates</copyright-holder>
      </permissions>
      <self-uri xlink:href="https://www.jimgs.com/ojs/index.php/journal/article/view/149"/>
      <kwd-group xml:lang="en">
        <kwd>Polycystic Ovary Syndrome (PCOS)</kwd>
        <kwd>PCSK9 inhibitors</kwd>
        <kwd>Dyslipidemia management</kwd>
        <kwd>Cardio-metabolic complications</kwd>
        <kwd>Statins vs. PCSK9 efficacy</kwd>
      </kwd-group>
      <custom-meta-group/>
    </article-meta>
  </front>
  <body/>
  <back>
    <ref-list>
      <ref id="R1">
        <mixed-citation>Goodman NF, Cobin RH, Futterweit W, Glueck JS, Legro RS, Carmina E. AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS, AMERICAN COLLEGE OF ENDOCRINOLOGY, AND ANDROGEN EXCESS AND PCOS SOCIETY DISEASE STATE CLINICAL REVIEW: GUIDE TO THE BEST PRACTICES IN THE EVALUATION AND TREATMENT OF POLYCYSTIC OVARY SYNDROME - PART 1. Endocrine Practice. 2015;21(11):1291-1300. doi:https://doi.org/10.4158/ep15748.dsc</mixed-citation>
      </ref>
      <ref id="R2">
        <mixed-citation>What are the symptoms of PCOS? https://www.nichd.nih.gov/. Published January 31, 2017. https://www.nichd.nih.gov/health/topics/pcos/conditio ninfo/symptoms</mixed-citation>
      </ref>
      <ref id="R3">
        <mixed-citation>Crespo RP, Bachega TASS, Mendonça BB, Gomes LG. An update of genetic basis of PCOS pathogenesis. Archives of Endocrinology and Metabolism. 2018;62(3):352-361.doi:https://doi.org/10.20945/2359-3997000000049</mixed-citation>
      </ref>
      <ref id="R4">
        <mixed-citation>What We Talk About When We Talk About PCOS. www.vice.com. https://www.vice.com/en/article/zmae5j/what-we-talk-about-when-we-talk-about-pcos</mixed-citation>
      </ref>
      <ref id="R5">
        <mixed-citation>About Polycystic Ovary Syndrome (PCOS). https://www.nichd.nih.gov/. https://www.nichd.nih.gov/health/topics/pcos/conditio ninfo</mixed-citation>
      </ref>
      <ref id="R6">
        <mixed-citation>Dawood A, Goyal M. Debates regarding lean patients with polycystic ovary syndrome: A narrative review. Journal of Human Reproductive Sciences. 2017;10(3):154.doi:https://doi.org/10.4103/jhrs.jhrs_77_17</mixed-citation>
      </ref>
      <ref id="R7">
        <mixed-citation>Legro RS, Arslanian SA, Ehrmann DA, et al. Diagnosis and Treatment of Polycystic Ovary Syndrome: An Endocrine Society Clinical Practice Guideline. The Journal of Clinical Endocrinology &amp; Metabolism. 2013;98(12):4565-4592.doi:https://doi.org/10.1210/jc.2013-2350</mixed-citation>
      </ref>
      <ref id="R8">
        <mixed-citation>Polycystic Ovarian Syndrome Treatment &amp; Management: Approach Considerations, Lifestyle Modifications, Drug Treatment. Medscape.com. Published September 16, 2018. https://emedicine.medscape.com/article/256806-treatment</mixed-citation>
      </ref>
      <ref id="R9">
        <mixed-citation>Huang G, Coviello A. Clinical update on screening, diagnosis and management of metabolic disorders and cardiovascular risk factors associated with polycystic ovary syndrome. Current Opinion in Endocrinology &amp; Diabetes and Obesity. 2012;19(6):512-519. doi:https://doi.org/10.1097/med.0b013e32835a000e</mixed-citation>
      </ref>
      <ref id="R10">
        <mixed-citation>Wang FF, Wu Y, Zhu YH, et al. Pharmacologic therapy to induce weight loss in women who have obesity/overweight with polycystic ovary syndrome: a systematic review and network meta-analysis. Obesity Reviews. 2018;19(10):1424-1445.doi:https://doi.org/10.1111/obr.12720</mixed-citation>
      </ref>
      <ref id="R11">
        <mixed-citation>Liu Q, Xie Y, Qu L, Zhang M, Mo Z. Dyslipidemia involvement in the development of polycystic ovary syndrome. Taiwanese Journal of Obstetrics and Gynecology. 2019;58(4):447-453.doi:https://doi.org/10.1016/j.tjog.2019.05.003</mixed-citation>
      </ref>
      <ref id="R12">
        <mixed-citation>Wild RA, Rizzo M, Clifton S, Carmina E. Lipid levels in polycystic ovary syndrome: systematic review and meta-analysis. Fertility and Sterility. 2011;95(3):1073-1079.e11.doi:https://doi.org/10.1016/j.fertnstert.2010.12.027</mixed-citation>
      </ref>
      <ref id="R13">
        <mixed-citation>Wekker V, van Dammen L, Koning A, et al. Long-term cardiometabolic disease risk in women with PCOS: a systematic review and meta-analysis. Human Reproduction Update. 2020;26(6):942-960. doi:https://doi.org/10.1093/humupd/dmaa029</mixed-citation>
      </ref>
      <ref id="R14">
        <mixed-citation>Zhu S, Zhang B, Jiang X, et al. Metabolic disturbances in non-obese women with polycystic ovary syndrome: a systematic review and meta-analysis. Fertility and Sterility. 2019;111(1):168-177. doi:https://doi.org/10.1016/j.fertnstert.2018.09.013</mixed-citation>
      </ref>
      <ref id="R15">
        <mixed-citation>Zhao L, Zhu Z, Lou H, et al. Polycystic ovary syndrome (PCOS) and the risk of coronary heart disease (CHD): a meta-analysis. Oncotarget. 2016;7(23):33715-33721.doi:https://doi.org/10.18632/oncotarget.9553</mixed-citation>
      </ref>
      <ref id="R16">
        <mixed-citation>Yanes L, Romero DG, Reckelhoff JF. Cardiometabolic Features of Polycystic Ovary Syndrome: Role of Androgens. Physiology. 2017;32(5):357-366. doi:https://doi.org/10.1152/physiol.00030.2016</mixed-citation>
      </ref>
      <ref id="R17">
        <mixed-citation>Osibogun O, Ogunmoroti O, Michos ED. Polycystic ovary syndrome and cardiometabolic risk: Opportunities for cardiovascular disease prevention. Trends in Cardiovascular Medicine. 2020;30(7):399-404. doi:https://doi.org/10.1016/j.tcm.2019.08.010</mixed-citation>
      </ref>
      <ref id="R18">
        <mixed-citation>Sanchez-Garrido MA, Tena-Sempere M. Metabolic dysfunction in polycystic ovary syndrome: Pathogenic role of androgen excess and potential therapeutic strategies. Molecular Metabolism. 2020;35:100937. doi:https://doi.org/10.1016/j.molmet.2020.01.001</mixed-citation>
      </ref>
      <ref id="R19">
        <mixed-citation>Yang R, Yang S, Li R, Liu P, Qiao J, Zhang Y. Effects of hyperandrogenism on metabolic abnormalities in patients with polycystic ovary syndrome: a meta-analysis. Reproductive Biology and Endocrinology. 2016;14(1). doi:https://doi.org/10.1186/s12958-016-0203-8</mixed-citation>
      </ref>
      <ref id="R20">
        <mixed-citation>Valkenburg O, R.P.M. Steegers‐Theunissen, H.P.M. Smedts, et al. A More Atherogenic Serum Lipoprotein Profile Is Present in Women with Polycystic Ovary Syndrome: A Case-Control Study. The Journal of Clinical Endocrinology and Metabolism. 2008;93(2):470-476. doi:https://doi.org/10.1210/jc.2007-1756</mixed-citation>
      </ref>
      <ref id="R21">
        <mixed-citation>Zhang Y, Suo Y, Yang L, et al. Effect of PCSK9 Inhibitor on Blood Lipid Levels in Patients with High and Very-High CVD Risk: A Systematic Review and Meta-Analysis. Cardiology Research and Practice. 2022;2022:1-13.doi:https://doi.org/10.1155/2022/8729003</mixed-citation>
      </ref>
      <ref id="R22">
        <mixed-citation>Bergeron N, Phan BAP, Ding Y, Fong A, Krauss RM. Proprotein Convertase Subtilisin/Kexin Type 9 Inhibition. Circulation. 2015;132(17):1648-1666. doi:https://doi.org/10.1161/circulationaha.115.016080</mixed-citation>
      </ref>
      <ref id="R23">
        <mixed-citation>Li C, Lin L, Zhang W, et al. Efficiency and Safety of Proprotein Convertase Subtilisin/Kexin 9 Monoclonal Antibody on Hypercholesterolemia: A Meta‐Analysis of 20 Randomized Controlled Trials. 2015;4(6). doi:https://doi.org/10.1161/jaha.115.001937</mixed-citation>
      </ref>
      <ref id="R24">
        <mixed-citation>Bär S, Räber I, Koskinas KC, Christoph Schlapbach, Lorenz Räber. Transient injection site reaction to alirocumab during immune system activation: a case series. European Heart Journal - Case Reports. 2022;6(5). doi:https://doi.org/10.1093/ehjcr/ytac187</mixed-citation>
      </ref>
      <ref id="R25">
        <mixed-citation>di Mauro G, Zinzi A, Scavone C, et al. PCSK9 Inhibitors and Neurocognitive Adverse Drug Reactions: Analysis of Individual Case Safety Reports from the Eudravigilance Database. Drug Safety. 2020;44(3):337-349.doi:https://doi.org/10.1007/s40264-020-01021-3</mixed-citation>
      </ref>
      <ref id="R26">
        <mixed-citation>Kazi DS, Moran AE, Coxson PG, et al. Cost-effectiveness of PCSK9 Inhibitor Therapy in Patients With Heterozygous Familial Hypercholesterolemia or Atherosclerotic Cardiovascular Disease. JAMA. 2016;316(7):743.doi:https://doi.org/10.1001/jama.2016.11004</mixed-citation>
      </ref>
      <ref id="R27">
        <mixed-citation>Kosmas CE, Skavdis A, Sourlas A, et al. Safety and Tolerability of PCSK9 Inhibitors: Current Insights. Clinical Pharmacology : Advances and Applications. 2020;12:191-202. doi:https://doi.org/10.2147/CPAA.S288831</mixed-citation>
      </ref>
      <ref id="R28">
        <mixed-citation>amilial Hypercholesterolemia and Pregnancy. American College of Cardiology. https://www.acc.org/latest-in-cardiology/articles/2018/05/10/13/51/familial-hypercholesterolemia-and-pregnancy#:~:text=PCSK9%20inhibitors%20have%2 0not%20been</mixed-citation>
      </ref>
      <ref id="R29">
        <mixed-citation>Wang M, Zhao D, Xu L, et al. Role of PCSK9 in lipid metabolic disorders and ovarian dysfunction in polycystic ovary syndrome. Metabolism. 2019;94:47-58. doi:10.1016/j.metabol.2019.02.002</mixed-citation>
      </ref>
      <ref id="R30">
        <mixed-citation>Bizoń A, Franik G, Madej P. The role of proprotein convertase subtilisin/kexin type-9 concentration and paraoxonase 1 activities in the blood of women with polycystic ovary syndrome. Environ Toxicol Pharmacol. 2021;84:103612. doi:10.1016/j.etap.2021.103612</mixed-citation>
      </ref>
      <ref id="R31">
        <mixed-citation>Moazzeni DR. PCSK9 Inhibitors: The New Frontier in Cholesterol Management. Heartcare Sydney. Published August 20, 2023. https://heartcare.sydney/pcsk9-inhibitors/</mixed-citation>
      </ref>
      <ref id="R32">
        <mixed-citation>Schulz R, Andreadou I, Ferdinandy P. Editorial: PCSK9: Importance in Physiology and Pathophysiology. Frontiers in Physiology. 2021;12. doi:https://doi.org/10.3389/fphys.2021.706115</mixed-citation>
      </ref>
    </ref-list>
  </back>
</article>
