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  <front>
    <journal-meta>
      <journal-id journal-id-type="ojs">journal</journal-id>
      <journal-title-group>
        <journal-title xml:lang="en">Journal For International Medical Graduates</journal-title>
        <abbrev-journal-title xml:lang="en">Journal For International Medical Graduates</abbrev-journal-title>
      </journal-title-group>
      <publisher>
        <publisher-name>California Institute of Behavioral Neurosciences and Psychology</publisher-name>
        <publisher-loc>
          <country>US</country>
          <uri>https://www.cibnp.com</uri>
        </publisher-loc>
      </publisher>
      <issn pub-type="epub">2832-9864</issn>
      <self-uri xlink:href="https://www.jimgs.com/ojs/index.php/journal"/>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id">143</article-id>
      <article-categories>
        <subj-group xml:lang="en" subj-group-type="heading">
          <subject>Articles</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title xml:lang="en">“Beyond the Onset: A Comprehensive Analysis of Risk Factors and Etiological Mechanisms in Central Precocious Puberty”- a Systematic Review</article-title>
      </title-group>
      <contrib-group content-type="author">
        <contrib corresp="yes">
          <name-alternatives>
            <string-name specific-use="display">Thota Priyanka</string-name>
            <name name-style="western" specific-use="primary">
              <surname>Priyanka</surname>
              <given-names>Thota</given-names>
            </name>
          </name-alternatives>
          <email>priyanka.thota@gmail.com</email>
        </contrib>
        <contrib>
          <name-alternatives>
            <string-name specific-use="display">Peresuodei Tariladei</string-name>
            <name name-style="western" specific-use="primary">
              <surname>Tariladei</surname>
              <given-names>Peresuodei</given-names>
            </name>
          </name-alternatives>
          <email>peresuodei.tariladei@jimgs.com</email>
        </contrib>
        <contrib>
          <name-alternatives>
            <string-name specific-use="display">Gill Abhishek</string-name>
            <name name-style="western" specific-use="primary">
              <surname>Abhishek</surname>
              <given-names>Gill</given-names>
            </name>
          </name-alternatives>
          <email>gill.abhishek@jimgs.com</email>
        </contrib>
        <contrib>
          <name-alternatives>
            <string-name specific-use="display">Orji Chijioke</string-name>
            <name name-style="western" specific-use="primary">
              <surname>Chijioke</surname>
              <given-names>Orji</given-names>
            </name>
          </name-alternatives>
          <email>orji.chijioke@jimgs.com</email>
        </contrib>
        <contrib>
          <name-alternatives>
            <string-name specific-use="display">Reghefaoui Maiss</string-name>
            <name name-style="western" specific-use="primary">
              <surname>Maiss</surname>
              <given-names>Reghefaoui</given-names>
            </name>
          </name-alternatives>
          <email>reghefaoui.maiss@jimgs.com</email>
        </contrib>
        <contrib>
          <name-alternatives>
            <string-name specific-use="display">Michell Saavedra Michell</string-name>
            <name name-style="western" specific-use="primary">
              <surname>Michell</surname>
              <given-names>Michell Saavedra</given-names>
            </name>
          </name-alternatives>
          <email>michell.saavedra.michell@jimgs.com</email>
        </contrib>
        <contrib>
          <name-alternatives>
            <string-name specific-use="display">Safeera Khan</string-name>
            <name name-style="western" specific-use="primary">
              <surname>Khan</surname>
              <given-names>Safeera</given-names>
            </name>
          </name-alternatives>
          <email>safeerakhan79@gmail.com</email>
        </contrib>
      </contrib-group>
      <pub-date date-type="pub" publication-format="epub">
        <day>03</day>
        <month>11</month>
        <year>2023</year>
      </pub-date>
      <pub-history>
        <event event-type="received">
          <event-desc>Received: <date date-type="received" iso-8601-date="2023-11-03T09:55:08+00:00"><day>3</day><month>11</month><year>2023</year></date></event-desc>
        </event>
      </pub-history>
      <permissions>
        <copyright-statement>Copyright (c) 2023 Journal For International Medical Graduates</copyright-statement>
        <copyright-year>2023</copyright-year>
        <copyright-holder>Journal For International Medical Graduates</copyright-holder>
      </permissions>
      <self-uri xlink:href="https://www.jimgs.com/ojs/index.php/journal/article/view/143"/>
      <kwd-group xml:lang="en">
        <kwd>Central precocious puberty</kwd>
        <kwd>risk factors</kwd>
        <kwd>pediatric population</kwd>
        <kwd>adolescent</kwd>
        <kwd>endocrinology</kwd>
      </kwd-group>
      <custom-meta-group/>
    </article-meta>
  </front>
  <body/>
  <back>
    <ref-list>
      <ref id="R1">
        <mixed-citation>Teilmann G , Pedersen CB , Jensen TK , Skakkebaek NE , Juul A. Prevalence and incidence of precocious pubertal development in Denmark: an epidemiologic study based on national registries. Pediatrics. 2005;116:1323–1328. 10.1542/peds.2005-0012</mixed-citation>
      </ref>
      <ref id="R2">
        <mixed-citation>Soriano-Guillen L , Corripio R , Labarta JI, et al. . Central precocious puberty in children living in Spain: incidence, prevalence, and influence of adoption and immigration. J Clin Endocrinol Metab. 2010;95:4305–4313. 10.1210/jc.2010-1025</mixed-citation>
      </ref>
      <ref id="R3">
        <mixed-citation>Page MJ, McKenzie JE, Bossuyt PM, et al.: The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021, 29:71. 10.1136/bmj.n71</mixed-citation>
      </ref>
      <ref id="R4">
        <mixed-citation>Cheng CK, Leung PC. Molecular biology of gonadotropin-releasing hormone (GnRH)-I, GnRH-II, and their receptors in humans. Endocr Rev. 2005;26(2):283–306. 10.1210/er.2003-0039</mixed-citation>
      </ref>
      <ref id="R5">
        <mixed-citation>Wang L, Guo W, Shen X, et al. Different dendritic domains of the GnRH neuron underlie the pulse and surge modes of GnRH secretion in female mice. Elife. 2020;9:e53945. https://doi.org/10.7554/eLife.53945</mixed-citation>
      </ref>
      <ref id="R6">
        <mixed-citation>de Roux N, Genin E, Carel JC, Matsuda F, Chaussain JL, Milgrom E. Hypogonadotropic hypogonadism due to loss of function of the KiSSl-derived peptide receptor GPR54. Proc Natl Acad Sci. 2003;100(19):10972–10976. 10.1073/pnas.1834399100</mixed-citation>
      </ref>
      <ref id="R7">
        <mixed-citation>Seminara SB, Messager S, Chatzidaki EE, et al. The GPR54 gene as a regulator of puberty. N Engl J Med. 2003;349(17):1614–1627. 10.1056/NEJMoa035322</mixed-citation>
      </ref>
      <ref id="R8">
        <mixed-citation>Topaloglu AK, Tello JA, Kotan LD, et al. Inactivating KISS1 mutation and hypogonadotropic hypogonadism. N Engl J Med. 2012;366(7):629–635. 10.1056/NEJMoa1111184</mixed-citation>
      </ref>
      <ref id="R9">
        <mixed-citation>Maione L, Bouvattier C, Kaiser UB. Central precocious puberty: Recent advances in understanding the aetiology and in the clinical approach. Clin Endocrinol (Oxf). 2021;95(4):542-555. 10.1111/cen.14475</mixed-citation>
      </ref>
      <ref id="R10">
        <mixed-citation>Topaloglu AK, Reimann F, Guclu M, et al. TAC3 and TACR3 mutations in familial hypogonadotropic hypogonadism reveal a key role for Neurokinin B in the central control of reproduction. Nat Genet. 2009;41(3):354–358. 10.1038/ng.306</mixed-citation>
      </ref>
      <ref id="R11">
        <mixed-citation>Hrabovszky E, Borsay BA, Racz K, et al. Substance P immunoreactivity exhibits frequent colocalization with kisspeptin and neurokinin B in the human infundibular region. PLoS One. 2013;8(8):e72369. https://doi.org/10.1371/journal.pone.0072369</mixed-citation>
      </ref>
      <ref id="R12">
        <mixed-citation>Prevot V Glial-neuronal-endothelial interactions are involved in the control of GnRH secretion. J Neuroendocrinol. 2002;14(3):247–255. 10.1046/j.0007-1331.2001.00772.x</mixed-citation>
      </ref>
      <ref id="R13">
        <mixed-citation>Chachlaki K, Garthwaite J, Prevot V. The gentle art of saying NO: how nitric oxide gets things done in the hypothalamus. Nat Rev Endocrinol. 2017;13(9):521–535. 10.1038/nrendo.2017.69</mixed-citation>
      </ref>
      <ref id="R14">
        <mixed-citation>Abreu AP, Dauber A, Macedo DB, et al. Central precocious puberty caused by mutations in the imprinted gene MKRN3. N Engl J Med. 2013;368(26):2467–2475. 10.1056/NEJMoa1302160</mixed-citation>
      </ref>
      <ref id="R15">
        <mixed-citation>Abreu AP, Toro CA, Song YB, et al. MKRN3 inhibits the reproductive axis through actions in kisspeptin-expressing neurons. J Clin Investig. 2020;130(8):4486–4500. 10.1172/JCI136564</mixed-citation>
      </ref>
      <ref id="R16">
        <mixed-citation>Heras V, Sangiao-Alvarellos S, Manfredi-Lozano M, et al. Hypothalamic miR-30 regulates puberty onset via repression of the puberty-suppressing factor, Mkrn3. PLoS Biol. 2019;17(11):e3000532. 10.1371/journal.pbio.3000532</mixed-citation>
      </ref>
      <ref id="R17">
        <mixed-citation>Dauber A, Cunha-Silva M, Macedo DB, et al. Paternally inherited DLK1 deletion associated with familial central precocious puberty. J Clin Endocrinol Metab. 2017;102(5):1557–1567. 10.1210/jc.2016-3677</mixed-citation>
      </ref>
      <ref id="R18">
        <mixed-citation>Silveira LG, Noel SD, Silveira-Neto AP, et al. Mutations of the KISS1 gene in disorders of puberty. J Clin Endocrinol Metab. 2010;95(5):2276–2280.</mixed-citation>
      </ref>
      <ref id="R19">
        <mixed-citation>Teles MG, Bianco SD, Brito VN, et al. A GPR54-activating mutation in a patient with central precocious puberty. N Engl J Med. 2008;358(7):709–715. 10.1056/NEJMoa073443</mixed-citation>
      </ref>
      <ref id="R20">
        <mixed-citation>Demurger F, Ichkou A, Mougou-Zerelli S, et al. New insights into genotype-phenotype correlation for GLI3 mutations. Eur J Hum Genet. 2015;23(1):92–102. 10.1038/ejhg.2014.62</mixed-citation>
      </ref>
      <ref id="R21">
        <mixed-citation>Mahdi H, Mester JL, Nizialek EA, Ngeow J, Michener C, Eng C. Germline PTEN, SDHB-D, and KLLN alterations in endometrial cancer patients with Cowden and Cowden-like syndromes: an international, multicenter, prospective study. Cancer. 2015;121(5):688–696. 10.1002/cncr.29106</mixed-citation>
      </ref>
      <ref id="R22">
        <mixed-citation>Kagami M, Nagasaki K, Kosaki R, et al. Temple syndrome: comprehensive molecular and clinical findings in 32 Japanese patients. Genet Med. 2017;19(12):1356–1366. 10.1038/gim.2017.53</mixed-citation>
      </ref>
      <ref id="R23">
        <mixed-citation>Ludwig NG, Radaeli RF, Silva MM, et al. A boy with Prader-Willi syndrome: unmasking precocious puberty during growth hormone replacement therapy. Arch Endocrinol Metab. 2016;60(6):596–600. 10.1590/2359-3997000000196</mixed-citation>
      </ref>
      <ref id="R24">
        <mixed-citation>Jung H, Carmel P, Schwartz MS, et al. Some hypothalamic hamartomas contain transforming growth factor alpha, a puberty-inducing growth factor, but not luteinizing hormone-releasing hormone neurons. J Clin Endocrinol Metab. 1999;84(12):4695–4701. 10.1210/jcem.84.12.6185</mixed-citation>
      </ref>
      <ref id="R25">
        <mixed-citation>Alomari SO, El Houshiemy MN, Bsat S, Moussalem CK, Allouh M, Omeis IA. Hypothalamic Hamartomas: A comprehensive review of literature - Part 2: Medical and surgical management update. Clin Neurol Neurosurg. 2020;195:106074. 10.1016/j.clineuro.2020.106076</mixed-citation>
      </ref>
      <ref id="R26">
        <mixed-citation>Virdis R, Sigorini M, Laiolo A, et al. Neurofibromatosis type 1 and precocious puberty. J Pediatr Endocrinol Metab. 2000;13(Suppl 1):841–844. 10.1515/jpem.2000.13.s1.841</mixed-citation>
      </ref>
      <ref id="R27">
        <mixed-citation>Krstevska-Konstantinova M, Charlier C, Craen M, et ai. Sexual precocity after immigration from developing countries to Belgium: evidence of previous exposure to organochlorine pesticides. Hum Reprod. 2001;16(5):1020–1026. 10.1093/humrep/16.5.1020</mixed-citation>
      </ref>
      <ref id="R28">
        <mixed-citation>Teilmann G, Pedersen CB, Skakkebaek NE, Jensen TK. Increased risk of precocious puberty in internationally adopted children in Denmark. Pediatrics. 2006;118(2):e391– 399. 10.1542/peds.2005-2939</mixed-citation>
      </ref>
      <ref id="R29">
        <mixed-citation>Donato J Jr, Cravo RM, Frazao R, et al. Leptin’s effect on puberty in mice is relayed by the ventral premammillary nucleus and does not require signaling in Kiss1 neurons. J Clin Investig. 2011;121(l):355–368. 10.1172/JCI45106</mixed-citation>
      </ref>
      <ref id="R30">
        <mixed-citation>Ross RA, Leon S, Madara JC, et al. PACAP neurons in the ventral premammillary nucleus regulate reproductive function in the female mouse. Elite. 2018;7:e35960. 10.7554/eLife.35960</mixed-citation>
      </ref>
      <ref id="R31">
        <mixed-citation>Marcovecchio ML, Chiarelli F. Obesity and growth during childhood and puberty. World Rev Nutr Diet. 2013;106:135–141. 10.1159/000342545</mixed-citation>
      </ref>
      <ref id="R32">
        <mixed-citation>Lee JE, Jung HW, Lee YJ, Lee YA. Early-life exposure to endocrine-disrupting chemicals and pubertal development in girls. Ann Pediatr Endocrinol Metab. 2019;24(2):78–91. 10.6065/apem.2019.24.2.78</mixed-citation>
      </ref>
      <ref id="R33">
        <mixed-citation>Partsch CJ, Sippell WG. Pathogenesis and epidemiology of precocious puberty. Effects of exogenous oestrogens. Hum Reprod Update. 2001;7(3):292–302. 10.1093/humupd/7.3.292</mixed-citation>
      </ref>
    </ref-list>
  </back>
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