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  <front>
    <journal-meta>
      <journal-id journal-id-type="ojs">journal</journal-id>
      <journal-title-group>
        <journal-title xml:lang="en">Journal For International Medical Graduates</journal-title>
        <abbrev-journal-title xml:lang="en">Journal For International Medical Graduates</abbrev-journal-title>
      </journal-title-group>
      <publisher>
        <publisher-name>California Institute of Behavioral Neurosciences and Psychology</publisher-name>
        <publisher-loc>
          <country>US</country>
          <uri>https://www.cibnp.com</uri>
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      <issn pub-type="epub">2832-9864</issn>
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    <article-meta>
      <article-id pub-id-type="publisher-id">137</article-id>
      <article-categories>
        <subj-group xml:lang="en" subj-group-type="heading">
          <subject>Articles</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title xml:lang="en">Prevention of Chronic Obstructive Pulmonary Disease (COPD) Exacerbations With Statin Therapy: A Systematic Review</article-title>
      </title-group>
      <contrib-group content-type="author">
        <contrib corresp="yes">
          <name-alternatives>
            <string-name specific-use="display">Khalid Javed</string-name>
            <name name-style="western" specific-use="primary">
              <surname>Javed</surname>
              <given-names>Khalid</given-names>
            </name>
          </name-alternatives>
          <email>kjaved0611@gmail.com</email>
          <xref ref-type="aff" rid="aff-1"/>
        </contrib>
        <contrib>
          <name-alternatives>
            <string-name specific-use="display">Prabhleen Kaur Manshahia</string-name>
            <name name-style="western" specific-use="primary">
              <surname>Manshahia</surname>
              <given-names>Prabhleen Kaur</given-names>
            </name>
          </name-alternatives>
          <email>manshahiapk065@gmail.com</email>
        </contrib>
        <contrib>
          <name-alternatives>
            <string-name specific-use="display">Shamsun Nahar</string-name>
            <name name-style="western" specific-use="primary">
              <surname>Nahar</surname>
              <given-names>Shamsun</given-names>
            </name>
          </name-alternatives>
          <email>shamsun.nahar.dmc@gmail.com</email>
        </contrib>
        <contrib>
          <name-alternatives>
            <string-name specific-use="display">Srishti Kanda</string-name>
            <name name-style="western" specific-use="primary">
              <surname>Kanda</surname>
              <given-names>Srishti</given-names>
            </name>
          </name-alternatives>
          <email>srishtikanda5@gmail.com</email>
        </contrib>
        <contrib>
          <name-alternatives>
            <string-name specific-use="display">Uzair Chatha</string-name>
            <name name-style="western" specific-use="primary">
              <surname>Chatha</surname>
              <given-names>Uzair</given-names>
            </name>
          </name-alternatives>
          <email>uzairchatha28@gmail.com</email>
        </contrib>
        <contrib>
          <name-alternatives>
            <string-name specific-use="display">Victor A. Odoma</string-name>
            <name name-style="western" specific-use="primary">
              <surname>Odoma</surname>
              <given-names>Victor A.</given-names>
            </name>
          </name-alternatives>
          <email>odomavictorameh@gmail.com</email>
        </contrib>
        <contrib>
          <name-alternatives>
            <string-name specific-use="display">Aakanksha Pitliya</string-name>
            <name name-style="western" specific-use="primary">
              <surname>Pitliya</surname>
              <given-names>Aakanksha</given-names>
            </name>
          </name-alternatives>
          <email>bubblypitliya@gmail.com</email>
        </contrib>
        <contrib>
          <name-alternatives>
            <string-name specific-use="display">Esraa M. AlEdani</string-name>
            <name name-style="western" specific-use="primary">
              <surname>AlEdani</surname>
              <given-names>Esraa M.</given-names>
            </name>
          </name-alternatives>
          <email>esraaaledani0gmail.com</email>
        </contrib>
        <contrib>
          <name-alternatives>
            <string-name specific-use="display">Japneet Bhangu</string-name>
            <name name-style="western" specific-use="primary">
              <surname>Bhangu</surname>
              <given-names>Japneet</given-names>
            </name>
          </name-alternatives>
          <email>japneetbhangu98@gmail.com</email>
        </contrib>
        <contrib>
          <name-alternatives>
            <string-name specific-use="display">Lubna Mohammed</string-name>
            <name name-style="western" specific-use="primary">
              <surname>Mohammed</surname>
              <given-names>Lubna</given-names>
            </name>
          </name-alternatives>
          <email>doclubna23@gmail.com</email>
        </contrib>
      </contrib-group>
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        <institution-wrap>
          <institution content-type="orgname">California Institute of Behavioral Neurosciences and Psychology (United States)</institution>
          <institution-id institution-id-type="ROR">https://ror.org/01ytd2n62</institution-id>
        </institution-wrap>
      </aff>
      <pub-date date-type="pub" publication-format="epub">
        <day>26</day>
        <month>09</month>
        <year>2023</year>
      </pub-date>
      <pub-history>
        <event event-type="received">
          <event-desc>Received: <date date-type="received" iso-8601-date="2023-09-26T09:15:21+00:00"><day>26</day><month>9</month><year>2023</year></date></event-desc>
        </event>
      </pub-history>
      <permissions>
        <copyright-statement>Copyright (c) 2023 Journal For International Medical Graduates</copyright-statement>
        <copyright-year>2023</copyright-year>
        <copyright-holder>Journal For International Medical Graduates</copyright-holder>
      </permissions>
      <self-uri xlink:href="https://www.jimgs.com/ojs/index.php/journal/article/view/137"/>
      <kwd-group xml:lang="en">
        <kwd>COPD</kwd>
        <kwd>statins</kwd>
        <kwd>inflammation</kwd>
        <kwd>chronicmobstructive pulmonary disease exacerbations</kwd>
        <kwd>emphysema</kwd>
        <kwd>albuterol</kwd>
      </kwd-group>
      <custom-meta-group/>
    </article-meta>
  </front>
  <body/>
  <back>
    <ref-list>
      <ref id="R1">
        <mixed-citation>Ajmera M, Shen C, Sambamoorthi, U: Association Between Statin Medications and COPD-Specific Outcomes: A Real-World Observational Study. Drugs Real World Outcomes. 2017, 4:9-19. 10.1007/s40801-016-0101-6</mixed-citation>
      </ref>
      <ref id="R2">
        <mixed-citation>Criner GJ, Connett JE, Aaron SD, et al.: Simvastatin for the Prevention of Exacerbations in Moderate-to-Severe COPD. N Engl J Med. 2014, 370:2201–10. 10.1056/nejmoa1403086</mixed-citation>
      </ref>
      <ref id="R3">
        <mixed-citation>Freyberg J, Landt EM, Afzal S, Nordestgaard BG, Dahl M: Low-density lipoprotein cholesterol and risk of COPD: Copenhagen General Population Study. ERJ Open Res. 2022, 9:00496–2022. 10.1183/23120541.00496-2022</mixed-citation>
      </ref>
      <ref id="R4">
        <mixed-citation>Soyseth V, Brekke PH, Smith P, Omland T: Statin use is associated with reduced mortality in COPD. European Respiratory Journal. 2006, 29:279–83. 10.1183/09031936.00106406</mixed-citation>
      </ref>
      <ref id="R5">
        <mixed-citation>Mortensen EM, Copeland LA, Pugh MJV, Restrepo MI, de Molina RM, Nakashima B, Anzueto A: Impact of statins and ACE inhibitors on mortality after COPD exacerbations. Respir Res. 2009, 10:. 10.1186/1465-9921-10-45</mixed-citation>
      </ref>
      <ref id="R6">
        <mixed-citation>Zhang W, Zhang Y, Li C-W, Jones P, Wang C, Fan Y: Effect of Statins on COPD. Chest. 2017, 152:1159–68. 10.1016/j.chest.2017.08.015</mixed-citation>
      </ref>
      <ref id="R7">
        <mixed-citation>Maneechotesuwan K, Wongkajornsilp A, Adcock I, et al.: Simvastatin Suppresses Airway IL-17 and Upregulates IL-10 in Patients With Stable COPD. 2015, 2015:1164-1176. 10.1378/chest.14-3138</mixed-citation>
      </ref>
      <ref id="R8">
        <mixed-citation>Raymakers AJN, Sadatsafavi M, Sin DD, De Vera MA, Lynd LD: The Impact of Statin Drug Use on All-Cause Mortality in Patients With COPD. Chest. 2017, 152:486–93. 10.1016/j.chest.2017.02.002</mixed-citation>
      </ref>
      <ref id="R9">
        <mixed-citation>Rossi A, Inciardi RM, Rossi A, et al.: Prognostic effects of rosuvastatin in patients with co-existing chronic obstructive pulmonary disease and chronic heart failure: A sub-analysis of GISSI-HF trial. Pulmonary Pharmacology &amp;amp; Therapeutics. 2017, 44:16–23. 10.1016/j.pupt.2017.03.001</mixed-citation>
      </ref>
      <ref id="R10">
        <mixed-citation>Balaguer C, Peralta A, Ríos Á, et al.: Effects of simvastatin in chronic obstructive pulmonary disease: Results of a pilot, randomized, placebo-controlled clinical trial. Contemporary Clinical Trials Communications. 2016, 2:91–6. 10.1016/j.conctc.2015.12.008</mixed-citation>
      </ref>
      <ref id="R11">
        <mixed-citation>Page MJ, McKenzie JE, Bossuyt PM, et al.: The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. Syst Rev. 2021, 10.1186/s13643-021-01626-4</mixed-citation>
      </ref>
      <ref id="R12">
        <mixed-citation>Petty TL: The history of COPD. International Journal of COPD. 2006, 1:3–14. 10.2147/copd.2006.1.1.3</mixed-citation>
      </ref>
      <ref id="R13">
        <mixed-citation>Fortis S, Quibrera PM, Comellas AP, et al.: Bronchodilator Responsiveness in Tobacco-Exposed People With or Without COPD. Chest. 2023, 163:502–14. 10.1016/j.chest.2022.11.009</mixed-citation>
      </ref>
      <ref id="R14">
        <mixed-citation>Wang M-T, Lo Y-W, Tsai C-L, Chang L-C, Malone DC, Chu C-L, Liou J-T: Statin Use and Risk of COPD Exacerbation Requiring Hospitalization. The American Journal of Medicine. 2013, 126:598-606.e2. 10.1016/j.amjmed.2013.01.036</mixed-citation>
      </ref>
      <ref id="R15">
        <mixed-citation>Fehrenbach H: Respir Res. 2001, 2:33. 10.1186/rr36</mixed-citation>
      </ref>
      <ref id="R16">
        <mixed-citation>Brandt J, Mandiga P: Histology, Alveolar Cells. 2023. https://www.ncbi.nlm.nih.gov/books/NBK557542..</mixed-citation>
      </ref>
      <ref id="R17">
        <mixed-citation>Meyer M, Jaspers I: Respiratory protease/antiprotease balance determines susceptibility to viral infection and can be modified by nutritional antioxidants. American Journal of Physiology-Lung Cellular and Molecular Physiology. 2015, 308:L1189–201. 10.1152/ajplung.00028.2015</mixed-citation>
      </ref>
      <ref id="R18">
        <mixed-citation>Johns D, Walters J, Walters H: Diagnosis and early detection of COPD using spirometry. 2014, 6:10.3978/j.issn.2072-1439.2014.08.18</mixed-citation>
      </ref>
      <ref id="R19">
        <mixed-citation>Di Stefano A, Caramori G, Ricciardolo FLM, Capelli A, Adcock IM, Donner CF: Cellular and molecular mechanisms in chronic obstructive pulmonary disease: an overview. Clin Exp Allergy. 2004, 34:1156–67. 10.1111/j.1365-2222.2004.02030.x</mixed-citation>
      </ref>
      <ref id="R20">
        <mixed-citation>Qureshi H, Sharafkhaneh A, Hanania NA: Chronic obstructive pulmonary disease exacerbations: latest evidence and clinical implications. Therapeutic Advances in Chronic Disease. 2014, 5:212–27. 10.1177/2040622314532862</mixed-citation>
      </ref>
      <ref id="R21">
        <mixed-citation>Bollmeier SG, Hartmann AP: Management of chronic obstructive pulmonary disease: A review focusing on exacerbations. American Journal of Health-System Pharmacy. 2020, 77:259–68. 10.1093/ajhp/zxz306</mixed-citation>
      </ref>
      <ref id="R22">
        <mixed-citation>Ucgun I, Metintas M, Moral H, Alatas F, Yildirim H, Erginel S: Predictors of hospital outcome and intubation in COPD patients admitted to the respiratory ICU for acute hypercapnic respiratory failure. Respiratory Medicine. 2006, 100:66–74. 10.1016/j.rmed.2005.04.005</mixed-citation>
      </ref>
      <ref id="R23">
        <mixed-citation>Mani RK, Schmidt W, Lund LW, Herth FJF: Respiratory Dialysis for Avoidance of Intubation in Acute Exacerbation of COPD. ASAIO Journal. 2013, 59:675–8. 10.1097/mat.0000000000000004</mixed-citation>
      </ref>
      <ref id="R24">
        <mixed-citation>Lu Y, Chang R, Yao J, Xu X, Teng Y, Cheng N: Effectiveness of long-term using statins in COPD – a network meta-analysis. Respir Res. 2019, 20:. 10.1186/s12931-019-0984-3</mixed-citation>
      </ref>
      <ref id="R25">
        <mixed-citation>Jain MK, Ridker PM: Anti-Inflammatory Effects of Statins: Clinical Evidence and Basic Mechanisms. Nat Rev Drug Discov. 2005, 4:977–87. 10.1038/nrd1901</mixed-citation>
      </ref>
      <ref id="R26">
        <mixed-citation>Damkjaer M, Håkansson K, Kallemose T, Ulrik CS, Godtfredsen N: Statins in High-Risk Chronic Obstructive Pulmonary Disease Outpatients: No Impact on Time to First Exacerbation and All-Cause Mortality – The STATUETTE Cohort Study. COPD. 2021, Volume 16:579–89. 10.2147/copd.s296472</mixed-citation>
      </ref>
      <ref id="R27">
        <mixed-citation>Ingebrigtsen TS, Marott JL, Nordestgaard BG, Lange P, Hallas J, Vestbo J: Statin use and exacerbations in individuals with chronic obstructive pulmonary disease. Thorax. 2014, 70:33–40. 10.1136/thoraxjnl-2014-205795</mixed-citation>
      </ref>
      <ref id="R28">
        <mixed-citation>Diamantis E, Kyriakos G, Quiles-Sanchez LV, Farmaki P, Troupis T: The Anti-Inflammatory Effects of Statins on Coronary Artery Disease: An Updated Review of the Literature. CCR. 2017, 13:. 10.2174/1573403x13666170426104611</mixed-citation>
      </ref>
      <ref id="R29">
        <mixed-citation>Graf J, Jörres RA, Lucke T, Nowak D, Vogelmeier CF, Ficker JH: Medical Treatment of COPD. Deutsches Ärzteblatt international. 2018. 10.3238/arztebl.2018.0599</mixed-citation>
      </ref>
      <ref id="R30">
        <mixed-citation>Mathioudakis AG, Vestbo J, Singh D: Long-Acting Bronchodilators for Chronic Obstructive Pulmonary Disease. Clinics in Chest Medicine. 2020, 41:463–74. 10.1016/j.ccm.2020.05.005</mixed-citation>
      </ref>
      <ref id="R31">
        <mixed-citation>Rabbat A, Guetta A, Lorut C, Lefebvre A, Roche N, Huchon G: Prise en charge des exacerbations aiguës de BPCO. Revue des Maladies Respiratoires. 2010, 27:939–53. 10.1016/j.rmr.2010.08.003</mixed-citation>
      </ref>
      <ref id="R32">
        <mixed-citation>Wildman MJ, O’Dea J, Kostopoulou O, Tindall M, Walia S, Khan Z: Variation in intubation decisions for patients with chronic obstructive pulmonary disease in one critical care network. QJM: An International Journal of Medicine. 2003, 96:583–91. 10.1093/qjmed/hcg104</mixed-citation>
      </ref>
      <ref id="R33">
        <mixed-citation>Ferrera MC, Labaki WW, Han MK: Advances in Chronic Obstructive Pulmonary Disease. Annu. Rev. Med. 2021, 72:119–34. 10.1146/annurev-med-080919-112707</mixed-citation>
      </ref>
      <ref id="R34">
        <mixed-citation>Yayan J, Bald M, Franke K-J: No Independent Influence of Statins on the Chronic Obstructive Pulmonary Disease Exacerbation Rate: A Cohort Observation Study Over 10 Years. IJGM. 2021, Volume 14:2883–92. 10.2147/ijgm.s309647</mixed-citation>
      </ref>
      <ref id="R35">
        <mixed-citation>Barnes PJ: Alveolar Macrophages as Orchestrators of COPD. COPD: Journal of Chronic Obstructive Pulmonary Disease. 2004, 1:59–70. 10.1081/copd-120028701</mixed-citation>
      </ref>
    </ref-list>
  </back>
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